How many gallons of gasoline does it take to drive a vehicle one mile?

It depends on the vehicle you are driving. Unless something is terribly wrong, it takes a fraction of a gallon to drive one mile. My 15-year-old Dodge gets 20 miles per gallon, meaning that one mile takes a twentieth, or 0.05, of one gallon. Some new models get 30 miles per gallon or more, so a mile would require 0.033 of a gallon or less.