What are the enemies of a quoll?

Quolls are threatened by loss of habitat, and especially from predation by introduced species such as dogs, cats and foxes, as well as competition from introduced species. The Spotted-tail Quoll in the north, and the Northern quoll, are both being killed off as a result of eating the Cane Toad, which is poisonous. Timber harvesting in Tasmania poses a significant threat to the quoll's shelter and removes hiding places for the quoll's prey, resulting in less food.

In some areas, because quolls have been known to kill poultry, farmers have deliberately baited the marsupials. This is an illegal practice, but it still happens. Further, quolls are known to ingest the 1080 poison put down to control populations of feral cats, foxes and rabbits.