How did Spain differ from the other countries during the renaissance?

During the early Renaissance Period (such as the mid-to-late 1400s) Spain was still involved in unification wars and the expulsion of Muslim Rulers. As a result, Spain was in no position to take the enlightened view of the Arts and Humanism that was prevailing in Northern Italy at the time. Spain also remained much more religious for a longer period of time because of the religious fervor required to embolden Christians on a holy war to "liberate" Spain from the "heathen" Muslims. In the later Renaissance (such as the mid-to-late 1500s), Spain was distinguished from other countries by its extreme relative wealth due to its expansive colonization of the Americas. This wealth would be completely consumed and abused in the 1600s because of the Wars of Religion (like the Eighty Years War and the Thirty Years War).