Is it possible for Adderall and Lexapro to counteract with each other?

In most cases yes it is safe to take this combination. Manytimes doctors use these in combination, because Adderall has a tendency to deplete the body's supply of serotonin. With that said Lexapro is ideal, since it is cleaner than many of the other antidepressants. In any event, caution should still be used, because combining the two drugs increases the risk of Serotonin Syndrome. Also, this syndrome will generally not develop right when you start but weeks after Lexapro has taken its full effect.

Here's why. Adderall causes your body to product more Serotonin. Once your body adjusts to the Adderall your body begins to produce less Serotonin and in some cases less than you did before. The benefit of Lexapro is that it blocks the reuptake of Serotonin, so when your body produces Serotonin it stays in the synapse and continues to work.

When an individual is just relying on their natural serotonin, SSRI antipredesants are not known to cause any problems, however, because Adderall is adding to the effect of the Lexapro and the Lexapro is blocking the metabolism of Serotonin, you may end up with Serotonin Syndrome.

The good news is this condition, while potentially deadly, it is very rarely deadly. In fact, you will usually just feel really irritable and icky generally before things get serious. When this happens, be sure to consult a doctor. The doctor will likely recommend that you temporarily and/or permanently reduce dosage based on the situation.