What is the difference between playing a guitar left-handed versus right-handed?

The main difference between playing a guitar left-handed and right-handed is the orientation of the instrument. A left-handed player holds the guitar with the neck in the right hand and strums with the left hand, while a right-handed player holds the guitar with the neck in the left hand and strums with the right hand. This affects the way chords are fingered and the overall technique used while playing.