During muscle contraction, ATP attaches to the myosin heads of the thick filaments in the muscle fibers. When ATP binds to myosin, it causes the myosin head to detach from the actin filament, allowing for a new cycle of cross-bridge formation and muscle contraction to occur. The hydrolysis of ATP then provides the energy necessary for the myosin head to pivot and pull the actin filament, leading to muscle shortening.
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