Is it harmful to take Tylenol after drinking alcohol?

Yes! The acetaminophen in Tylenol in combination with alcohol is toxic to your liver. This can kill you, and at the least poses a serious risk of doing permanent damage to your liver. NEVER take Tylenol or any other acetaminophen containing drug before, during, or after drinking alcohol. In fact.. you can drink a little bit of alcohol (no excess) with low doses of Tylenol (if you take it not regularly)... if you're not that old, your liver will be able to take it without any problem.