I am assuming that "inserts" mean "refills" (only the rubber blade, not the blade and frame which is commonly called "wiper blade"). I will recommend however, that you consider replacing the entire wiper blade - especially in colder climate with ice and snow - because the frame does go through a lot of use and abuse and for small difference in price, you're best off replacing the entire wiper blade.
That said, whether you replace the inserts with refills or you replace the entire blade, the 2005 Mercedes-Benz E320 has 26" front wipers.
Note, be sure to always look up your vehicle make, model and year in the application guide book at the store, or now-a-days you can google 'lookup wiper size'.
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