To change the rear axle seals on a 2000 GMC 3500, first, lift the vehicle and remove the rear wheels. Next, remove the brake assembly and the axle retaining bolts to pull out the axle shafts. After that, use a seal puller to remove the old seals from the axle housing, clean the area, and then install the new seals, ensuring they are seated properly. Finally, reassemble the axle shafts, brake assembly, and wheels, and lower the vehicle.
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