Cardiomegaly is not a condition requiring treatment - it is a symptom of another disease process. As such, the cardiomegaly is not treated, the underlying process is treated.
The most common cause of cardiomegaly is hypertension. Treatment of the hypertension may result in decreasing cardiomegaly, but this is not typical.
Other conditions which result in cardiomegaly include myocardial infarction, congestive heart failure, and pulmonary hypertension. Renal disease is also a less common cause. For congestive heart failure and myocardial infarction, ACE inhibitors can be used to help prevent remodeling of the heart and decrease cardiomegaly.
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