The thermostat on a 2004 Cadillac CTS is located in the engine compartment, specifically at the engine's front, near the water pump. To access it, you typically need to remove the upper radiator hose, which connects to the thermostat housing. The housing itself is usually secured with bolts, and once removed, you can replace the thermostat. Always consult the vehicle's service manual for specific instructions and safety precautions.
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