Serial numbers rarely affect a bill's value unless they're special in some way - e.g. low (00000006), repeating (12121212), symmetric (12344321), etc.
Far more important factors are the bill's date, condition, and series letter (the small letter next to the date; it may not be present however).
Also, any bill with a (*) in the serial number increases the value of your bill, sometimes by quite a bit.
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