Will a vehicle run without a transfer case?

A vehicle cannot run properly without a transfer case if it is equipped with four-wheel drive (4WD) or all-wheel drive (AWD), as the transfer case is essential for distributing power to both the front and rear axles. In vehicles with only two-wheel drive (2WD), the absence of a transfer case won't affect operation, but it may limit functionality if the vehicle is intended for off-road or challenging conditions. In summary, the vehicle's ability to run depends on its drivetrain configuration.