Is naproxen processed by the liver?

Naproxen is primarily metabolized in the liver through the cytochrome P450 enzyme system, specifically CYP1A2 and CYP2C19. However, a significant portion of the drug is excreted unchanged in the urine. While liver metabolism plays a role in its processing, the kidneys also play a crucial role in eliminating the drug from the body. Therefore, both organs are involved in the pharmacokinetics of naproxen.