Why does hemophilia does not follow the classic mendelian rule?

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2026-03-06 12:45

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Hemophilia does not follow classic Mendelian inheritance patterns because it is an X-linked recessive disorder. This means that the gene responsible for hemophilia is located on the X chromosome, and males, having only one X chromosome, are more likely to express the condition if they inherit the affected allele. In contrast, females have two X chromosomes, so they would need to inherit two copies of the mutated gene to exhibit the disorder, making hemophilia less common in females. This results in a characteristic inheritance pattern that diverges from Mendelian ratiOS typically seen in autosomal traits.

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