Can a female Maltese breed with a male rottweiler?

Yes the female Maltese can breed with a male Rottweiler, but it may hurt her. I say it may hurt her because the puppies will be too large for her tiny little body. The puppies will be too large growing inside of her let alone passing through her birth canal. You may say there is the option of a c section, well the puppies will still be too large growing inside of her. If you really wanted to see what a Maltese and a Rottweiler puppy will look like then, mate the female Rottweiler with the male Maltese. Using the female Rottweiler instead of the female Maltese would be a lot easier and safer, on you and the dog/puppies. The female Rottweiler has a lot more room in her uterus and in her birth canal than what the female Maltese.