In 1899, Felix Hoffmann, a German chemist, is best known for synthesizing acetylsalicylic acid, which is the active ingredient in aspirin. This discovery was significant because it provided a more stable and less irritating form of salicylic acid, a compound derived from willow bark that had been used for pain relief. Hoffmann's work led to the commercialization of aspirin by Bayer, making it one of the most widely used medications in history.
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