Can you find 3 pairs of drugs with opposing pharmacological effects and 3 pairs of drugs with similar pharmacological effects?

First:Adderall, Dexedrine, meth Vs. Alcohol and barbituates such as allobarbitol and phenobarbitol

Second:hmm..3 PAIRS?

1-caffiene and ephedrine, actuall caffiene potentiates ephedrine.

2-LSD and Psilocybe mushrooms (Psilocybin and Psilocyn)

3-Mescaline and 5meoDipt(Foxy) both produce vomiting and hallucinations