Does air resistance act on the surface of a snowflake when it is in motion?

Anything moving in air is acted on the by the air, including the snowflake. Air, a fluid, will interact in a dynamic way with anything around which it is moving. Air resistance is a factor with a snowflake, a rain drop or a hail stone. Aerodynamic principles apply. We investigate stuff like this, and fluid dynamics is the field of study.