Who claimed the largest area in the Americas during the late 1400s and early 1500s?

During the late 1400s and early 1500s, Spain claimed the largest area in the Americas following the voyages of Christopher Columbus and subsequent explorers. The Treaty of Tordesillas in 1494, brokered by the Pope, granted Spain rights to vast territories in the New World, leading to extensive conquests in regions such as present-day Mexico, Central America, and parts of South America. This expansion established Spain as a dominant colonial power in the Americas during that period.