How much tetrodotoxin can kill one?

Tetrodotoxin is a highly potent neurotoxin found in certain marine animals, such as pufferfish. As little as 1 to 2 milligrams of tetrodotoxin can be lethal to humans, depending on individual sensitivity and body weight. The toxin blocks sodium channels in nerves, leading to paralysis and potentially fatal respiratory failure. Due to its potency, even a tiny amount can be dangerous, making it crucial to avoid consumption of improperly prepared seafood known to contain the toxin.