A blinking check engine light on a 2000 Toyota Sienna typically indicates a serious issue, such as a misfire, that can damage the catalytic converter if not addressed promptly. It's important to stop driving the vehicle and diagnose the problem as soon as possible. You can use an OBD-II scanner to retrieve diagnostic trouble codes, or take the vehicle to a mechanic for a thorough inspection. Ignoring this warning could lead to more costly repairs down the line.
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