Is it safe to take Effexor and hydrocodone?

Combining Effexor (venlafaxine), an antidepressant, with hydrocodone, an opioid pain medication, can be risky. Both medications can affect serotonin levels and increase the risk of serotonin syndrome, a potentially life-threatening condition. Additionally, the combination may enhance sedation and respiratory depression. It's essential to consult a healthcare professional before taking these medications together to ensure safety and monitor for potential interactions.