How long does Tylenol stay in your system?

Tylenol (acetaminophen) will stay in your system up to 48 hours if you take therapeutic doses of around 1000mg. However, this depends on your liver and metabolites.

The half life is around 4-8 hours, so if you're worried about testing positive for it and want to be completely on the safe side, err to the side of 48 hours.