Can liver disease cause a false positive urine test for methamphetamine?

Yes, liver disease can potentially lead to false positive urine tests for methamphetamine. This occurs because liver dysfunction may alter the metabolism and excretion of various substances, including medications and metabolites that can be mistaken for methamphetamine. Additionally, certain liver conditions can cause the accumulation of compounds that may interfere with the test's specificity. Therefore, clinical correlation and further testing may be necessary to confirm any positive results.