How long is drive from Ft Myers to Key West?

The drive from Fort Myers to Key West typically takes around 3.5 to 4 hours, covering approximately 125 miles. The route primarily follows U.S. Highway 41 and then the scenic Overseas Highway (U.S. 1) through The Florida Keys. However, travel time can vary depending on traffic and road conditions. It's a beautiful drive with several opportunities to stop and enjoy the views.