How can I effectively remove weeds with thorns from my garden?

To effectively remove weeds with thorns from your garden, wear gloves to protect your hands, use a hand tool like a trowel or hoe to dig out the weeds at the root, making sure to remove the entire plant including the roots. Dispose of the weeds in a trash bag to prevent them from regrowing. Regularly inspect your garden for new weeds and remove them promptly to prevent them from spreading.