Both the Lewis and Clark expedition and the later expeditions, such as those led by Fremont or Pike, aimed to explore and map the uncharted western territories of the United States. They sought to expand knowledge of the geography, flora, fauna, and potential for settlement in these regions. However, while Lewis and Clark focused primarily on the Northwest Territory and the Missouri River, later expeditions ventured into different areas, such as the Rocky Mountains and the Southwest. Additionally, Lewis and Clark had the dual purpose of establishing trade with Native Americans, whereas subsequent expeditions often emphasized military and territorial claims.
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