What happens if you drink while taking methotrexate?

No you cannot drink with this medication. The drug itself is hard enough on your kidneys and you are required to take extra folic acid as the drug destroys it in your system that's why you have to do regular blood testing! Alcohol can cause damage to your kidneys and liver and especially so when on methotrexate. However the odd beer should not be too much of a problem.

Imagine what? Not having a cold one during the football game or at a bbq? That is scary. My RA (rheumatologist) doctor said it's fine to drink a few beers during the week. My blood test always come back fine and my doctor approves. Now a case a week may hurt the old liver or kidney but a couple beers here and there won't hurt. Live a little. We already have to deal with a crappy immune disease.