How do you set an epiphone guitar amp to play a guns n roses song?

To set an Epiphone guitar amp for a Guns N' Roses song, start by adjusting the gain to a moderate level to achieve a crunchy distortion, typical of Slash's tone. Set the EQ with the bass around 5, mids around 7, and treble around 6 to capture that signature sound. If your amp has a reverb setting, add a touch for ambiance, but keep it subtle. Finally, use the right pickup on your guitar, preferably the bridge pickup, to enhance the aggressive tone.