Mucinex DM, which contains guaifenesin and dextromethorphan, is generally considered safe to take with most antidepressants. However, it's important to consult with a healthcare provider or pharmacist before combining medications, as individual circumstances and specific antidepressants can vary. Some antidepressants can interact with dextromethorphan, potentially leading to increased side effects. Always follow professional guidance for your specific situation.
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