Will you lose weight from taking Cymbalta?

Any antidepressant can make you gain weight. but only a certain percentage of people will gain weight on an antidepressant. Cymbalta is not one of the worst, Paxil and Remeron would be. It is thought that a long term weight gain of a couple of pounds typically, like 1-2% of your body weight (2-5 pounds) can be expected, but benefits generally greatly outweigh the risks, and that more people DON'T gain weight while taking an antidepressant than the other way around.

On the other hand, some psychiatrists tell their patients that weight gain is an expected side effect of antidepressants due to changes their metabolism, and that weight gain is experienced by most of her patients.

Personal experience:

I have gained weight on all of the antidepressants I have tried (and there have been many). My internal medicine doctor told me that weight gain is expected on antidepressant drugs, including Cymbalta. It is true that some people don't gain weight but they are in the minority. For the majority of those who do gain weight, it isn't 1-2% of your body weight, but significantly higher. I have never gained less than 20 pounds despite maintaining a diet of around 1000 calories a day and exercising 5-6 times a week. Of course, if you are in the abyss it is worth the weight gain, but, know what you are getting yourself into.