What are contraindications for receiving t-PA?

Contraindications for receiving tissue plasminogen activator (t-PA) include a history of hemorrhagic stroke, recent major surgery or trauma, active bleeding, severe uncontrolled hypertension, and known bleeding disorders. Additionally, patients who have had a stroke or head injury within the past three months, or those with a significant risk of hemorrhage, should not receive t-PA. It is crucial to assess these factors to minimize the risk of serious complications.