Patients trust McMurphy in "One Flew Over the Cuckoo's Nest" because he embodies a sense of freedom and rebellion against the oppressive rules of the mental institution. His charismatic personality and willingness to challenge authority resonate with the patients, who feel disempowered. McMurphy's genuine care for their well-being and his ability to bring laughter and hope into their lives further solidify their trust in him. Ultimately, he represents a refreshing change from the dehumanizing environment they endure.
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