How did opposition to and subsequent rejection of the league of nations affect the US policy at the beginning of world war 2?

The opposition to and rejection of the League of Nations significantly impacted U.S. foreign policy at the onset of World War II. It fostered an isolationist sentiment, leading the U.S. to prioritize domestic issues over international engagement and to avoid entangling alliances. This reluctance to participate in global diplomacy hindered early efforts to confront rising totalitarian regimes in Europe and Asia. Ultimately, the U.S.'s isolationism delayed its involvement in the war until the attack on Pearl Harbor in 1941.