Can you take Tylenol PM with Tylenol 3?

No, this would exceed the recommended dose of acetaminophen. However, you could take just a Benadryl (diphenhydramine) with the Tylenol 3. It is the ingredient in Tylenol PM that makes you sleepy, without the extra acetaminophen.

Tylenol PM contains 500 mg of acetaminophen and 25 mg of diphenhydramine.

Tylenol 3 contains 300mg of acetaminophen and 30mg of codeine.

Recommended doses for adults are:

• 300-500 mg of acetaminophen every 4-6 hours, or up to 1000 mg every 6 hours; not to exceed 4000 mg of acetaminophen during a day

• 25-50 mg diphenhydramine every 4-6 hours, not to exceed 50-100 mg every 4-6 hours