Where are the receptors for water soluble hormones?

Receptors for water-soluble hormones are primarily located on the surface of target cells, embedded in the cell membrane. These receptors are typically proteins that interact with the hormone, triggering a cascade of intracellular signaling pathways. Because water-soluble hormones cannot easily cross the lipid bilayer of the cell membrane, their binding to surface receptors is essential for conveying their effects inside the cell.