What tribe was the first to be moved in the trail of tears?

The first tribe to be forcibly removed during the Trail of Tears was the Cherokee Nation. The U.S. government implemented the Indian Removal Act of 1830, leading to the displacement of thousands of Cherokees from their ancestral lands in the Southeast to designated Indian Territory west of the Mississippi River. The removal process was marked by suffering, hardship, and significant loss of life due to harsh conditions during the journey.