Which disease is most common in the US not caused by pathogens?

The most common disease in the U.S. not caused by pathogens is Heart disease. It encompasses various conditions affecting the heart and blood vessels, primarily due to factors such as poor diet, lack of exercise, smoking, and genetics. Heart disease remains a leading cause of death, highlighting the importance of lifestyle choices and preventive care. Regular check-ups and healthy lifestyle changes can significantly reduce the risk.