What is the name of a cartoon with a woman is the last human on earth?

The cartoon you're referring to is likely "The Last Man on Earth," which features a woman named Carol Pilbasian as one of the last survivors in a post-apocalyptic world. However, if you're looking for a purely animated series, "The Last Kids on Earth" has a similar theme but centers on a group of kids rather than focusing on a single woman as the last human. For a female-centric narrative, "I Am Legend" has been adapted into various forms, but it's primarily a film rather than a cartoon.