What should be done when a large leak of refrigerant occurs from a filled cylinder?

In the event of a large refrigerant leak from a filled cylinder, immediately evacuate the area to ensure safety, as refrigerants can be harmful or even toxic. Once everyone is at a safe distance, notify emergency services and the appropriate hazardous materials team. The cylinder should be assessed for damage, and if safe to do so, it may be moved to a well-ventilated area to allow for dispersion. Always follow local regulations and guidelines for handling refrigerant leaks.