Yes, mononucleosis, often caused by the Epstein-Barr virus (EBV), can affect monocytes. During the infection, there is typically an increase in atypical lymphocytes, but monocytes may also show changes in their numbers and function. This can lead to an immune response where monocytes play a role in fighting the infection, although they are not the primary cells affected. Overall, while monocytes are involved in the immune response during mononucleosis, the primary impact is observed in lymphocytes.
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