In space, astronauts use toothpaste similarly to how they do on Earth, applying it to a toothbrush. However, due to the lack of gravity, they must be careful to avoid swallowing the toothpaste or allowing it to float away. To mitigate this, astronauts often use a small amount of water to rinse, and special containers help keep the toothpaste and toothbrush secure during use. After brushing, they typically spit the residue into a specially designed waste container.
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