Wellbutrin, or bupropion, primarily affects the neurotransmitters dopamine and norepinephrine by inhibiting their reuptake, which can enhance their availability in the brain. While its primary mechanism does not directly target acetylcholine, some studies suggest that bupropion may have indirect effects on cholinergic systems. However, its main therapeutic effects are primarily linked to dopamine and norepinephrine modulation.
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