Caliber refers to the diameter of a bullet (bullet is the part of a cartridge that is fired out of the gun). A .223 caliber bullet is .223 inches across. It is normally used as a rifle cartridge. a .45 caliber bullet is more than twice as wide as a .223, and is usually used in pistols. The .223 is lighter- it weighs about 1/4 of a .45 bullet, and they are different shapes- .223 is usually pointed, the .45 is rounded.
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