What is the consequence of the red blood cell being a nucleate?

Red blood cells (RBCs) in mammals are anucleate, meaning they lack a nucleus. This adaptation allows for more space within the cell to accommodate hemoglobin, enhancing its capacity to carry oxygen. However, the absence of a nucleus also limits the RBC's ability to repair itself and undergo protein synthesis, leading to a finite lifespan of about 120 days and necessitating continuous production from the bone marrow.