Can you use supertech ST16 in a 2000 Chevy 6.0 2500?

I would not recommend you use any Supertech filter. This filter may or may not be of Excellent quality depending on who the manufacture is, which you have no idea of knowing. Why risk it with an expensive engine. I recommend you purchase an AC/Delco, Purolator, Wix, or Bosch quality filter for your truck.