What was a major U.S. route from Missouri to the Northwest in the 19th century?

A major U.S. route from Missouri to the Northwest in the 19th century was the Oregon Trail. This historic route, stretching approximately 2,170 miles, facilitated the westward migration of thousands of settlers seeking new opportunities in the Oregon Territory. It began in Independence, Missouri, and traversed through present-day states such as Kansas, Nebraska, Wyoming, and Idaho before reaching Oregon. The trail played a crucial role in the expansion of the United States and the settlement of the West.