Why are there more safety precautions for R-410A then with other popular refrigerant like R-22 and R-404A?

R-410A has more safety precautions due to its higher operating pressures compared to R-22 and R-404A, which can increase the risk of leaks and system failures. Additionally, R-410A is a hydrofluorocarbon (HFC) with a higher global warming potential, prompting stricter regulations and guidelines for its use and handling. These factors necessitate enhanced safety measures to protect both workers and the environment during installation, maintenance, and disposal processes.