I'm going to say no. I get very car sick and took Dramamine for a long time. I started taking Zoloft about two years ago. this past spring break i used the patch version of Dramamine and it made me absolutely worse. I was sweating, shaking, virtually in tears. I called my dr and he told me to take the patch off. When i took it off i could feel the difference immediately. i wasn't shaking, sweating or anything. I still had to sit in the front because of my car sickness, but NO don't take Dramamine if you are taking Zoloft
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